JEE Main · 2022 · 25 Jul 2022 · Shift 1 · Biomolecules

During the denaturation of proteins, which of these structures will remain intact?

(A)Primary✓ Correct
(B)Secondary
(C)Tertiary
(D)Quaternary

Answer: (A)

Solution

Protein denaturation involves the disruption of the three-dimensional structure of a protein without breaking the peptide bonds. The primary structure (the sequence of amino acids linked by peptide bonds) remains intact during denaturation. However, the secondary structure (α-helices, β-sheets), tertiary structure (3D folding), and quaternary structure (multi-subunit assembly) are all disrupted by denaturation agents such as heat, pH changes, or chemical denaturants. Only the covalent peptide bonds of the primary structure survive denaturation.

JEE Main · 2022 · 25 Jul 2022 · Shift 1 · Single correct option

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